@dryfly, I have PiHole running on two Rpi4. I installed OpenVPN on one of them via the install script on this page: PIVPN: Simplest way to setup a VPN and installed Wireguard on the second RPi4 using the same script. Both work well and I use either to view my cameras.
OK, you have answered what I'm asking. Maybe I was not clear, as I am running OpenVPN on the Asus AC86U as the server. The Raspberry pi is only used to run Pi-hole.
I really fly by the seat on my pants on stuff like this as I'm not too sharp on networking stuff. I just follow instructions and hope it works. The reason I ask the question is I'd like to know any potential problems using my VPN and PI-hole before I dive in.