Can Blue Iris communicate across multiple subnets

Jan 5, 2018
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We are toying with the idea of purchasing Blue Iris. We have IP cams in multiple subnets which are accessible because of LAN-to-LAN VPNs. Any issues here?
 
That's a comforting response, if I could venture a follow-up question:

Does Blue Iris "discover" the cameras, or does it latch on to the camera you specify by IP address?