I always said I would get a new F150 when they had the self driving features (figuring it was 5 years off) and then they come up with that (as an add on, what next year) but I think I'll was a year to let them get more bugs worked out of the whole new model. Plus, I just don't put on many miles a year anymore. (I'm not sure what engine I would get.)
I think the 2020 had the auto braking and I think lane keeping.
I have a 2021 F150, and it will drive it's self. Works well, but you have to keep your eye on it. My 2019 Acura RLX has it too. They operate off of the lines on the roadway, and it the lines go off to the side like in a construction zone the car will drive that way also. There has been some good changes in the years, they operate more smoothly with less operator interaction, but you still have to be ready to correct it if needed. Out on the open highway, you seldom need to help, but in the heavy city traffic, be ready.
Engine wise, if you are towing all the time and needing all the power in the world, get the V8 as it's solid and can be modified easily for more power.
If you drive the truck as a car, and seldom haul much of a load, get the 2.7 echo boost. If you haul a fair amount and tow occasionally, get the 3.5 echo boost, it will give you the torque of the V8 and the gas mileage of the echo boost. The 2021 gives you a 10 speed dual clutch in all of the combos. I haven't drove the new 3.5 echo boost with the hybrid.
In a race of the V8 against the 3.5, the V8, both 4x4, the v8 gets off the line a bit quicker, but by 100 foot the echo boost pulls along side, then passes the V8 and never looks back all the way to legal + speeds.