Christmas of last year, I got my wife (she was 64 then) a Remington RM380. I got it because it was easy for to her rack the slide; she could not rack other popular small, pocket 380's, tried several....not enough hand strength. Mouse guns have very strong springs to offset for their small mass and help produce needed recoil to eject, cock, etc....you know how it works.
Well, since then the arthritis in my left thumb and the carpal tunnel in the 3 middle fingers off my right hand (shooting hand) have gotten so bad I'm in the same boat, albeit for a different reason. So I picked one up for myself this summer...nice shooting for a pocketable "mouse" gun. All metal, no sharp edges, smooth pull from a pocket holster....and made up the road about 75 miles in Huntsville.
In the controlled, comfortable surroundings of a shooting range or my back yard (6.5 acres) it's not pleasant to intentionally rack a slide on anything, although if in a life-or-death situation, I imagine adrenaline and panic would offset any pain in my hands and fingers.....I honestly hope I never find out.
When we walk the dogs up the road (we're in the middle of a National Forest area), I carry my Bersa Thunder Pro 9mm, but it's WAY too big for concealed carry. It's a tad easier to rack it's slide, mainly because you've got a lot more slide to hang onto and it's nicely checkered for grip.