Hopefully this proves helpful to folks, but I thought to post a quick guide how to get Blue Iris working on a Mac without using a virtual machine or Boot Camp. The below guide intends to install Blue Iris version 5; not sure it will work with version 4. It actually works pretty well with minimal glitches, at least on my Mac Mini Server. Caveats: I may have forgotten some items, but these come to mind: Hardware acceleration may or may not work depending on your hardware. Sometimes in the mobile app, videos don't show a preview image. CPU usage does not always report correctly and often shows a very unusual value such as a negative. In General Settings under Clips and Archiving, check “Do NOT Monitor free space.” In General Settings under Startup, ensure only “Require run-as Administrator…,” “Prevent the Windows screensaver while Blue Iris…,” and “Prevent power management from…” In General Settings under Web server, change C:\Program Files\Blue Iris 5\www to C:\Program Files\Blue Iris 5\ui3 Step-by-Step: Head over to Gcenx/WineskinServer and click on “View Raw” to download the “WineskinWinery.app.tar.7z” file. Fully decompress the file you just download and move the app file to your Applications folder. Launch the Wineskin app. Ensure the box “Hide engines that require XQuartz” is checked. Once presented with the main window, click on the “+” sign and add the newest engine. The name will start with “WS10WineCX64Bit.” Now click “Create New Blank Wrapper,” type “Blue Iris” for the name, and click Ok. Wait for a minute or two. If you get a warning about Wineskin not being optimized for your Mac, just click Ok. If you receive any warnings about NET or Gecko, allow it to install. Once the completion window appears, click “View wrapper in Finder” and move the “Blue Iris” app to your Applications folder. Launch the Blue Iris app. Once launched, click on “Advanced” and navigate to the “Options” menu. Unclick “Map User Mac OS X folders in wrapper.” Navigate to the “Configuration” menu and click “Install Software” and then “Choose Executable Software.” Select the Blue Iris exe file downloaded from the Blue Iris website. Go through the Windows installer as you normally would leaving all install locations as default. It will likely ask to install C++ so be sure to do so by clicking “Next.” Upon completion uncheck “Launch Blue Iris” and “Read Documentation” boxes. A pop-up will come up asking you to choose an executive. From the pulldown, select the one ending with “BlueIrisAdmin.exe.” Go to your Applications folder and right click on the Blue Iris app and select “Show Package Contents.” Navigate to drive_c --> Program Files --> Blue Iris 5 Unzip the ui3.zip file. OPTIONAL: Go back to your Wineskin window which should still be open and on the “Configuration” menu. OPTIONAL: Click “Browse” under “Icon” on the right and navigate to Blue Iris app --> drive_c --> Program Files --> Blue Iris 5 --> ui3 --> ui3 and select “launcher-icon.png." Quit Wineskin. Launch the Blue Iris app and setup as usual. Enjoy!