Yes; I wish I could say more, but I've never used a 4k camera. So I can't advise for sure what you would need to decode fourteen 4k streams, but at that resolution on that many cameras, I feel that you're going to have to use the new substream feature. That's simply an astronomical amount of data to decode real time otherwise!
Most IP cameras have at least two video streams: The main stream in full resolution, and one or more sub streams at a lower resolution. Until recently,
Blue Iris has always streamed (and decoded) the full main stream, and processed that image for motion detection. The problem is that people are now beginning to use 2k and 4k cameras, vastly increasing the amount of processing power needed to decode the video and process each frame for motion on each camera. The newly introduced substream feature in Blue Iris now allows it to stream (and decode) a sub stream—often at VGA resolution—to watch for motion. It takes very little CPU and RAM to decode a 0.3mp stream compared to an 8mp stream! When motion is detected, Blue Iris starts capturing the full resolution main stream and saving it directly to the disk (no decoding required). As a result, Blue Iris never has to decode the full 4k image unless you're viewing a camera live in solo, or playing back a saved clip; and when it does, it's just one camera at a time instead of all 14 at the same time. This is the first part of how motion detection should have always been done, and I am so pleased to see Blue Iris finally doing it! With fourteen 4k cameras, the difference in processing power required is improved by an order of several magnitude by using substream technology. (The second part of how motion detection is supposed to be done is to use the motion vectors encoded into the encoded H.264 frames by the camera instead of decoding the stream and doing a bitmap comparison, but nobody seems to be that smart yet.)
Some people enable the Blue Iris option to "Limit decoding unless required" to reduce CPU load. NEVER do this. It completely cripples your motion detector as it only decodes key frames—so only one image every 1-5 seconds. You might get away with it indoors, but the results will be completely unpredictable outside, and you won't be able to use the MAKE time to filter out brief aberrations.