Port forwarding is only as unsafe as the service you are exposing.
VPN servers are designed with cybersecurity as a top priority and most modern VPNs are generally considered safe by security experts, especially when the VPN server is kept up to date and uses modern best practices for cryptography-related settings.
Blue Iris's web server does not prioritize cybersecurity at the same level as a VPN server. It is not even close if we're being honest. That said, I personally trust Blue Iris's web server enough to forward a port to it and not bother with the VPN (because it IS an added hassle, there's no denying that). I would never do that for your typical IP camera or NVR appliance.