Unfortunately, this app is probably the most CPU-intensive method of remote viewing for both machines involved, but mostly for the
Blue Iris machine. Blue Iris must encode frames as jpeg for every camera simultaneously when using this app. The client machine must decode them. There are a lot of performance options to affect the CPU usage of the client app, but the only one that really affects Blue Iris' CPU usage is the delay between image refreshes. Fewer refreshes is less load for blueiris.exe.
I'm assuming your 5MP cameras are all running at 10fps. That is typically the max resolution for chinese 5MP cameras, but some of the more expensive brands can offer higher.
For your situation, I recommend you go into
Blue Iris Options >
Cameras tab, and limit live preview rate to something low. It is possible that limiting it to 10 fps will help, but you might have to go lower to see any CPU usage improvement. In my experience, the main Blue Iris interface is the most efficient viewing method since it does not require recompressing the video. However high frame rates can still be taxing.
Since I only access my Blue Iris machine remotely, I do not need a high frame rate on its live view so I have this limited to 1fps. At this setting it uses almost no extra CPU at all to have the Blue Iris interface open. I also have Blue Iris run as a Windows service which you can configure in the Startup tab, as this allows Blue Iris to run in the background without having its interface open. Therefore it uses slightly less CPU time.
Now chances are this will not result in enough of a CPU usage drop to be comfortable. The next step would be to lower the frame rate of at least some of the cameras. You must lower it in the camera's web interface to get the full CPU savings effect. Then, also lower the frame rate of the camera in Blue Iris to match, unless you have Blue Iris set to auto adjust frame rate. This should have a very significant effect on CPU usage. Chances are your 5MP cameras max out at 10 FPS, but if any of them run higher, I encourage you to reduce those frame rates first. I have 3x 5MP cameras that I run at 5 FPS.